2. Academic Validation
  3. Lignan Glycosides from the Twigs of Chaenomeles sinensis and Their Biological Activities

Lignan Glycosides from the Twigs of Chaenomeles sinensis and Their Biological Activities

  • J Nat Prod. 2015 May 22;78(5):1174-8. doi: 10.1021/acs.jnatprod.5b00090.
Chung Sub Kim 1,  Lalita Subedi,  Sun Yeou Kim,  Sang Un Choi 2,  Ki Hyun Kim 1,  Kang Ro Lee 1
Affiliations

Affiliations

  • 1 †Natural Products Laboratory, School of Pharmacy, Sungkyunkwan University, Suwon 440-746, Republic of Korea.
  • 2 ⊥Korea Research Institute of Chemical Technology, Daejeon 305-343, Republic of Korea.
PMID: 25894905 DOI: 10.1021/acs.jnatprod.5b00090
Abstract

Phytochemical investigation of the twigs of Chaenomeles sinensis led to the isolation and identification of six new lignan glycosides, chaenomiside A-F (1-6), along with five known ones (7-11). Their chemical structures were determined by spectroscopic methods, including NMR, MS, ECD, and GC/MS analyses. All the isolated compounds (1-11) were tested for their inhibitory effects on nitric oxide (NO) production in lipopolysaccharide-activated murine microglial cells and the secretion of nerve growth factor (NGF) in a C6 rat glioma cell line. Compound 6 significantly reduced NO levels in the murine microglia BV2 cells with an IC50 value of 21.3 μM, and compounds 1, 3, and 6 were potent stimulants of NGF release with stimulation levels of 151.74 ± 6.77%, 144.31 ± 7.49%, and 167.61 ± 18.5%, respectively.

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