2. Academic Validation
  3. The potential of follicle-stimulating hormone peptide-modified triptolide-loaded nanoparticles to induce a mouse model of premature ovarian insufficiency

The potential of follicle-stimulating hormone peptide-modified triptolide-loaded nanoparticles to induce a mouse model of premature ovarian insufficiency

  • Int J Nanomedicine. 2015 Apr 7;10:2765-74. doi: 10.2147/IJN.S72593.
Xiu-Ying Chen 1,  Wu-Lian Chen 2,  Min Ma 1,  Chao Gu 3,  Xi-Rong Xiao 3,  Bin Li 3
Affiliations

Affiliations

  • 1 Obstetrics and Gynecology Hospital, Fudan University, Shanghai, People's Republic of China ; Department of Obstetrics and Gynecology of Shanghai Medical College, Fudan University, Shanghai, People's Republic of China ; Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Fudan University, Shanghai, People's Republic of China.
  • 2 State Key Laboratory of Molecular Engineering of Polymers, Department of Macromolecular Science, Fudan University, Shanghai, People's Republic of China.
  • 3 Obstetrics and Gynecology Hospital, Fudan University, Shanghai, People's Republic of China ; Department of Obstetrics and Gynecology of Shanghai Medical College, Fudan University, Shanghai, People's Republic of China.
PMID: 25897221 DOI: 10.2147/IJN.S72593
Abstract

The use of triptolide (TP) is limited by its poor water solubility and severe toxicity. In this study, we developed an active drug delivery system (TP-loaded nanoparticles) that could help improve the water solubility of TP and decrease its toxicity. Then, we investigated whether TP-loaded nanoparticles could be used to establish a novel premature ovarian insufficiency mouse model. The mice treated with TP-loaded nanoparticles for 35 days displayed normal growth, decreased serum antimullerian hormone, prominent ovarian fibrosis and vacuolar changes, fewer follicles and corpus lutea, increased collapsed oocytes and follicle Apoptosis, and sterility. In conclusion, this model appears to show the reproductive characteristics associated with premature ovarian insufficiency in women and will allow us to study the mechanism of the effects of traditional Chinese medicine on gonadal toxicity.

Keywords

animal model; drug delivery; nanoparticles; peptide; premature ovarian insufficiency.

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