2. Academic Validation
  3. Genetic variants in interleukin 7 receptor α chain (IL-7Ra) are associated with multiple sclerosis risk and disability progression in Central European Slovak population

Genetic variants in interleukin 7 receptor α chain (IL-7Ra) are associated with multiple sclerosis risk and disability progression in Central European Slovak population

  • J Neuroimmunol. 2015 May 15;282:80-4. doi: 10.1016/j.jneuroim.2015.03.010.
Daniel Čierny 1,  Sandra Hányšová 2,  Jozef Michalik 3,  Ema Kantorová 4,  Egon Kurča 5,  Mária Škereňová 6,  Ján Lehotský 7
Affiliations

Affiliations

  • 1 Department of Medical Biochemistry, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Malá Hora 4, 036 01 Martin, Slovak Republic. Electronic address: dacierny@gmail.com.
  • 2 Department of Medical Biochemistry, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Malá Hora 4, 036 01 Martin, Slovak Republic. Electronic address: hanysova@jfmed.uniba.sk.
  • 3 Department of Neurology, Jessenius Faculty of Medicine in Martin and Martin University Hospital, Comenius University in Bratislava, Kollárova 2, 036 59 Martin, Slovak Republic. Electronic address: michalik@unm.sk.
  • 4 Department of Neurology, Jessenius Faculty of Medicine in Martin and Martin University Hospital, Comenius University in Bratislava, Kollárova 2, 036 59 Martin, Slovak Republic. Electronic address: ema.kantorova@gmail.com.
  • 5 Department of Neurology, Jessenius Faculty of Medicine in Martin and Martin University Hospital, Comenius University in Bratislava, Kollárova 2, 036 59 Martin, Slovak Republic. Electronic address: egonkurca@gmail.com.
  • 6 Department of Clinical Biochemistry, Jessenius Faculty of Medicine in Martin and Martin University Hospital, Comenius University in Bratislava, Kollárova 2, 036 59 Martin, Slovak Republic. Electronic address: molbiol@mfn.sk.
  • 7 Department of Medical Biochemistry, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Malá Hora 4, 036 01 Martin, Slovak Republic. Electronic address: lehotsky@jfmed.uniba.sk.
PMID: 25903732 DOI: 10.1016/j.jneuroim.2015.03.010
Abstract

In this study, we determined the association between rs6897932 in interleukin 7 receptor α (IL7Ra) gene and the risk and disability progression of multiple sclerosis (MS) in 270 MS patients and 303 controls. We found allele C to be associated with the risk of MS and minor allele T to be protective against MS development. Moreover, we revealed for the first time that rs6897932 in IL7Ra gene is associated with the progression of MS, evaluated by MSSS scores. The minor allele T and genotype TT are protective against a rapid disability progression in MS in the Central European Slovak population.

Keywords

Disability progression; Gene polymorphism; IL7 receptor alpha gene; MSSS; Multiple sclerosis; rs6897932.

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