2. Academic Validation
  3. Anti-inflammatory Terpenoids from the Leaves and Twigs of Dysoxylum gotadhora

Anti-inflammatory Terpenoids from the Leaves and Twigs of Dysoxylum gotadhora

  • J Nat Prod. 2015 May 22;78(5):1037-44. doi: 10.1021/np5010196.
Kan Jiang 1,  Lu-Lin Chen 2,  Shu-Fang Wang 2,  Yi Wang 2,  Ya Li 1,  Kun Gao 1
Affiliations

Affiliations

  • 1 †State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, People's Republic of China.
  • 2 ‡Pharmaceutical Informatics Institute, Zhejiang University, Hangzhou 310058, People's Republic of China.
PMID: 25945867 DOI: 10.1021/np5010196
Abstract

Nine new Terpenoids (1-3, 5-10), including three cyclolanostane triterpenoids (1-3) and six isopimarane Diterpenoids (5-10), along with six known Terpenoids (4, 11-15), were isolated from the leaves and twigs of Dysoxylum gotadhora. Compound 1 represents a class of rare natural 21,24-epoxy cyclolanostane-type triterpenoids, and compounds 2 and 3 are the first examples of 21,25-epoxy cyclolanostane-type triterpenoids. Compounds 1, 2, 4, 8, and 15 exhibited noteworthy inhibition of nitric oxide production induced by lipopolysaccharide in RAW 264.7 cells with IC50 values of 25.5, 41.5, 27.4, 14.5, and 45.2 μM, respectively.

Figures