2. Academic Validation
  3. Geranylated flavanones from Paulownia coreana and their inhibitory effects on nitric oxide production

Geranylated flavanones from Paulownia coreana and their inhibitory effects on nitric oxide production

  • Chem Pharm Bull (Tokyo). 2015;63(5):384-7. doi: 10.1248/cpb.c14-00839.
Qinghao Jin 1,  Chul Lee,  Jin Woo Lee,  Dongho Lee,  Youngsoo Kim,  Jin Tae Hong,  Jin Sook Kim,  Joo-Hwan Kim,  Mi Kyeong Lee,  Bang Yeon Hwang
Affiliations

Affiliation

  • 1 College of Pharmacy, Chungbuk National University.
PMID: 25948332 DOI: 10.1248/cpb.c14-00839
Abstract

The activity-guided fractionation of the MeOH extract of the flower of Paulownia coreana led to the isolation of a new geranylated flavanone, 3'-O-methyl-5'-hydroxydiplacol (1), along with 10 known compounds (2-11). Their structures were determined using spectroscopic techniques, which included one and two dimensional (1- and 2D)-NMR. Among the isolates, compounds 1-6 showed potent inhibitory activities against lipopolysaccharide (LPS)-induced nitric oxide production with IC50 values ranging 1.48 to 16.66 µM.

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