A new antibacterial octaketide and cytotoxic phenylethanoid glycosides from Pogostemon cablin (Blanco) Benth

Bioorg Med Chem Lett. 2015 Jul 15;25(14):2834-6. doi: 10.1016/j.bmcl.2015.04.094.

Ki Hyun Kim ¹, Christine Beemelmanns ², Jon Clardy ³, Shugeng Cao ⁴

Affiliations

1 Natural Product Research Laboratory, School of Pharmacy, Sungkyunkwan University, Suwon 440-746, Republic of Korea.
2 Leibniz Institute for Natural Product Research and Infection Biology e.V., Hans-Knöll-Institute (HKI), Beutenbergstrasse 11a, 07745 Jena, Germany.
3 Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, United States.
4 Natural Products & Experimental Therapeutics, University of Hawaii Cancer Center, 701 Ilalo Street, Honolulu, HI 96813, United States. Electronic address: scao@cc.hawaii.edu.

PMID: 25981688 DOI: 10.1016/j.bmcl.2015.04.094

Abstract

A new octaketide, named cytosporone V (1), and two Other known phenylethanoid glycosides (2-3), were isolated from the aerial parts of Pogostemon cablin (Blanco) Benth. The structure of 1 was elucidated by a combination of extensive spectroscopic analyses, including extensive 2D NMR and HR-MS. Compounds 1-3 displayed weak Antibacterial activity against two gram-positive bacteria, Bacillus subtilis and Staphylococcus aureus. All isolates were also evaluated for their antiproliferative activities against four human tumor cell lines (A549, SK-OV-3, SK-MEL-2, and HCT-15). Compounds 2 and 3 showed significant cytotoxicity against A549, SK-OV-3, SK-MEL-2, and HCT-15 cell lines with IC50 values ranging from 2.73 to 9.52 μM.

Keywords

Antibacterial activity; Cytotoxicity; Lamiaceae; Octaketide; Pogostemon cablin.

Name
Email *

	Sorry, but the email address you supplied was invalid.