Synthesis and antiproliferative activity of some novel benzo-fused imidazo[1,8]naphthyridinones

Bioorg Med Chem Lett. 2015 Jul 1;25(13):2621-3. doi: 10.1016/j.bmcl.2015.04.093.

Vassiliki Giannouli ¹, Ioannis K Kostakis ¹, Nicole Pouli ², Panagiotis Marakos ¹, Pinelopi Samara ³, Ourania Tsitsilonis ³

Affiliations

1 Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Athens, Panepistimiopolis-Zografou, Athens 15771, Greece.
2 Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Athens, Panepistimiopolis-Zografou, Athens 15771, Greece. Electronic address: pouli@pharm.uoa.gr.
3 Department of Animal & Human Physiology, Faculty of Biology, University of Athens, Panepistimiopolis, Athens 15784, Greece.

PMID: 25998504 DOI: 10.1016/j.bmcl.2015.04.093

Abstract

A number of new substituted fused naphthyridinones has been prepared and their antiproliferative activity was evaluated against a panel of seven human tumor cell lines, including the variant MES-SA/Dx5, reported to be 100-fold resistant to doxorubicin. Certain derivatives exhibited interesting cytotoxic properties, possessing IC50 values in a low μM range.

Keywords

Acridines; Cytotoxicity; Imidazonaphthyridinones; Multi-drug resistance.

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