2. Academic Validation
  3. Bis-arylidene oxindole-betulinic Acid conjugate: a fluorescent cancer cell detector with potent anticancer activity

Bis-arylidene oxindole-betulinic Acid conjugate: a fluorescent cancer cell detector with potent anticancer activity

  • ACS Med Chem Lett. 2015 Apr 13;6(5):612-6. doi: 10.1021/acsmedchemlett.5b00095.
Abhishek Pal 1,  Anirban Ganguly 2,  Sumit Chowdhuri 3,  Md Yousuf 3,  Avijit Ghosh 3,  Ayan Kumar Barui 2,  Rajesh Kotcherlakota 2,  Susanta Adhikari 3,  Rajkumar Banerjee 2
Affiliations

Affiliations

  • 1 Department of Chemistry, University of Calcutta , 92, A.P.C. Road, Kolkata 700 009, India ; Department of Organic Chemistry, Indian Association for Cultivation of Science , Jadavpur, Kolkata 700 032, India.
  • 2 Biomaterials Group, CSIR-Indian Institute of Chemical Technology , Hyderabad 500 007, India.
  • 3 Department of Chemistry, University of Calcutta , 92, A.P.C. Road, Kolkata 700 009, India.
PMID: 26005543 DOI: 10.1021/acsmedchemlett.5b00095
Abstract

Molecules offering simultaneous detection and killing of Cancer cells are advantageous. Hybrid of Cancer cell-selective, ROS generator betulinic acid and bis-arylidene oxindole with amino propyl-linker is developed. With intrinsic fluorescence, the molecule exhibited Cancer cell-specific residence. Further, it generated ROS, triggered Apoptosis, and exhibited potent cytotoxicity in Cancer cells selectively. We demonstrate the first example and use of isatins as betulinic acid conjugate for selective detection of Cancer and subsequent killing of Cancer cells via Apoptosis.

Keywords

Fluorescent oxindole; ROS; apoptosis; betulinic acid; cancer cell detection.

Figures