1. Academic Validation
  2. Bioactive compounds isolated from submerged fermentations of the Chilean fungus Stereum rameale

Bioactive compounds isolated from submerged fermentations of the Chilean fungus Stereum rameale

  • Z Naturforsch C J Biosci. 2015;70(3-4):97-102. doi: 10.1515/znc-2015-5005.
Pedro Aqueveque Carlos Leonardo Céspedes José Becerra Marcelo Dávila Olov Sterner
Abstract

Liquid fermentations of the fungus Stereum rameale (N° 2511) yielded extracts with Antibacterial activity. The Antibacterial activity reached its peak after 216 h of stirring. Bioassay-guided fractionation methods were employed for the isolation of the bioactive metabolites. Three known compounds were identified: MS-3 (1), vibralactone (2) and vibralactone B (3). The three compounds showed Antibacterial activity as a function of their concentration. Minimal bactericidal concentrations (MBC) of compound 1 against Gram-positive bacteria were as follows: Bacillus cereus (50 μg/mL), Bacillus subtilis (10 μg/mL) and Staphylococcus aureus (100 μg/mL). Compounds 2 and 3 were active only against Gram-negative bacteria. The MBC of compound 2 against Escherichia coli was 200 μg/mL. Compound 3 inhibited significantly the growth of E. coli and Pseudomonas aeruginosa, with MBC values of 50 and 100 μg/mL, respectively.

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