2. Academic Validation
  3. Chemical constituents isolated from the Mongolian medicinal plant Sophora alopecuroides L. and their inhibitory effects on LPS-induced nitric oxide production in RAW 264.7 macrophages

Chemical constituents isolated from the Mongolian medicinal plant Sophora alopecuroides L. and their inhibitory effects on LPS-induced nitric oxide production in RAW 264.7 macrophages

  • Bioorg Med Chem Lett. 2015 Aug 15;25(16):3314-8. doi: 10.1016/j.bmcl.2015.05.062.
Jaeyoung Kwon 1,  Sunita Basnet 1,  Jin Woo Lee 2,  Eun-Kyoung Seo 3,  Nanzad Tsevegsuren 4,  Bang Yeon Hwang 2,  Dongho Lee 5
Affiliations

Affiliations

  • 1 Department of Biosystems and Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul 136-713, Republic of Korea.
  • 2 College of Pharmacy, Chungbuk National University, Cheongju 362-763, Republic of Korea.
  • 3 College of Pharmacy, Ewha Womans University, Seoul 120-750, Republic of Korea.
  • 4 Laboratory of Functional Foods and Natural Products, Department of Chemistry, School of Arts and Sciences, National University of Mongolia, Mongolia.
  • 5 Department of Biosystems and Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul 136-713, Republic of Korea. Electronic address: dongholee@korea.ac.kr.
PMID: 26073007 DOI: 10.1016/j.bmcl.2015.05.062
Abstract

Three new flavonostilbenes, alopecurones M-O (1-3), were isolated from the root bark of Sophora alopecuroides L. together with 21 known compounds. The structures of the isolated compounds were elucidated by using NMR, MS, and CD spectroscopic data. All isolates were evaluated for their potential to inhibit LPS-induced nitric oxide production in RAW 264.7 cells.

Keywords

Flavonostilbenes; Nitric oxide production inhibitor; Sophora alopecuroides L..

Figures