Anti-influenza activities of polyphenols from the medicinal mushroom Phellinus baumii

Bioorg Med Chem Lett. 2015 Aug 15;25(16):3256-60. doi: 10.1016/j.bmcl.2015.05.081.

Byung Soon Hwang ¹, In-Kyoung Lee ¹, Hwa Jung Choi ², Bong-Sik Yun ³

Affiliations

1 Division of Biotechnology and Advanced Institute of Environment and Bioscience, Chonbuk National University, 79 Gobong-ro, Iksan-si 570-752, Republic of Korea.
2 Department of Beauty Science, Kwangju Women's University, 165 Sanjeong-dong, Gwangsan-gu, Kwangju 506-713, Republic of Korea.
3 Division of Biotechnology and Advanced Institute of Environment and Bioscience, Chonbuk National University, 79 Gobong-ro, Iksan-si 570-752, Republic of Korea. Electronic address: bsyun@jbnu.ac.kr.

PMID: 26077494 DOI: 10.1016/j.bmcl.2015.05.081

Abstract

Five Polyphenols were isolated from the ethanolic extract of the fruiting bodies of Phellinus baumii. These compounds were identified by various spectroscopic methods as hispidin, hypholomine B, inoscavin A, davallialactone, and phelligridin D. All compounds inhibited noncompetitively H1N1, H5N1, and H3N2 neuraminidase activity and reduced the amount of virally-induced cytopathic effect (CPE) according to an MDCK cell-based assay.

Keywords

Anti-influenza; Cytopathic effect; Neuraminidase inhibition; Phellinus baumii; Polyphenol.

Name
Email *

	Sorry, but the email address you supplied was invalid.