2. Academic Validation
  3. An Isoflavone from Leiophyllum buxifolium and Its Antiproliferative Effect

An Isoflavone from Leiophyllum buxifolium and Its Antiproliferative Effect

  • J Nat Prod. 2015 Jul 24;78(7):1748-51. doi: 10.1021/acs.jnatprod.5b00100.
Dan Tian 1,  John R Porter 1
Affiliations

Affiliation

  • 1 †Program in Pharmacognosy, Department of Chemistry and Biochemistry, and ‡Department of Biological Sciences, University of the Sciences, Philadelphia, Pennsylvania 19104, United States.
PMID: 26086179 DOI: 10.1021/acs.jnatprod.5b00100
Abstract

A new C-methylisoflavone, isosideroxylin (1), and a known C-methylflavone, sideroxylin (2), were isolated from the EtOAc extract of the leaves of Leiophyllum buxifolium. The two compounds were evaluated with the sulforhodamine B assay for their antiproliferative effects against ER(-) MDA-MB-231 and ER(+) MCF-7 breast Cancer cell lines and the NIH3T3 mouse fibroblast cell line. Isosideroxylin (1) displayed a selective antiproliferative effect against MDA-MB-231 cells.

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