2. Academic Validation
  3. Potential therapeutic agents for circulatory diseases from Bauhinia glauca Benth.subsp. pernervosa. (Da Ye Guan Men)

Potential therapeutic agents for circulatory diseases from Bauhinia glauca Benth.subsp. pernervosa. (Da Ye Guan Men)

  • Bioorg Med Chem Lett. 2015 Aug 15;25(16):3217-20. doi: 10.1016/j.bmcl.2015.05.089.
Yingzhan Tang 1,  Junhong Ling 2,  Peng Zhang 3,  Xiangrong Zhang 4,  Na Zhang 3,  Wenli Wang 1,  Jiayuan Li 1,  Ning Li 5
Affiliations

Affiliations

  • 1 School of Traditional Chinese Materia Medica 49(#), Shenyang Pharmaceutical University, Wenhua Road 103, Shenyang 110016, China; Key Laboratory of Structure-Based Drug Design and Discovery (Shenyang Pharmaceutical University), Ministry of Education, Wenhua Road 103, Shenyang 110016, China.
  • 2 School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Wenhua Road 103, Shenyang 110016, China.
  • 3 Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China.
  • 4 School of Traditional Chinese Materia Medica 49(#), Shenyang Pharmaceutical University, Wenhua Road 103, Shenyang 110016, China.
  • 5 School of Traditional Chinese Materia Medica 49(#), Shenyang Pharmaceutical University, Wenhua Road 103, Shenyang 110016, China; Key Laboratory of Structure-Based Drug Design and Discovery (Shenyang Pharmaceutical University), Ministry of Education, Wenhua Road 103, Shenyang 110016, China. Electronic address: liningsypharm@163.com.
PMID: 26096681 DOI: 10.1016/j.bmcl.2015.05.089
Abstract

Because of platelets as critical factor in the formation of pathogenic thrombi, anti-platelet activities have been selected as therapeutic target for various circulatory diseases. In order to find potential therapeutic agents, bioassay-directed separation of Bauhinia glauca Benth.subsp. pernervosa. (called Da Ye Guan Men as a traditional Chinese medicine) was performed to get 29 main components (compounds 1-29) from the bioactive part of this herbal. It was the first time to focus on the composition with anti-platelet aggregation activities for this traditional Chinese medicine. The constituents, characterized from the effective extract, were established on the basis of extensive spectral data analysis. Then their anti-platelet aggregation effects were evaluated systematically. On the basis of the chemical profile and biological assay, it was suggested that the flavonoid composition (5 and 18) should be responsible for the anti-platelet aggregation of the herbal because of their significant activities. The primary structure and activity relationship was also discussed briefly.

Keywords

Bauhinia glauca Benth.subsp. pernervosa.; Bioassay-directed separation; Effective flavonoid composition; Platelet aggregation inhibiting activities; Structure and activity relationship.

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