2. Academic Validation
  3. Cytotoxic triterpene saponins from Cercodemas anceps

Cytotoxic triterpene saponins from Cercodemas anceps

  • Bioorg Med Chem Lett. 2015 Aug 15;25(16):3151-6. doi: 10.1016/j.bmcl.2015.06.005.
Nguyen Xuan Cuong 1,  Le Thi Vien 1,  Tran Thi Hong Hanh 1,  Nguyen Phuong Thao 1,  Do Thi Thao 2,  Nguyen Van Thanh 1,  Nguyen Hoai Nam 1,  Do Cong Thung 3,  Phan Van Kiem 1,  Chau Van Minh 4
Affiliations

Affiliations

  • 1 Institute of Marine Biochemistry (IMBC), Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Caugiay, Hanoi, Viet Nam.
  • 2 Institute of Biotechnology (IBT), VAST, 18 Hoang Quoc Viet, Caugiay, Hanoi, Viet Nam.
  • 3 Institute of Marine Environment and Resources (IMER), VAST, 246 Da Nang, Haiphong, Viet Nam.
  • 4 Institute of Marine Biochemistry (IMBC), Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Caugiay, Hanoi, Viet Nam. Electronic address: cvminh@vast.vn.
PMID: 26099533 DOI: 10.1016/j.bmcl.2015.06.005
Abstract

Seven holostane-type triterpene saponins (1-7), including five new compounds namely cercodemasoides A-E (2-6), were isolated from the sea cucumber Cercodemas anceps. Their structures were elucidated on the basis of spectroscopic evidence including HR ESI MS, ESI MS/MS, 1D and 2D NMR. The cytotoxic effects of isolated compounds were evaluated by SRB method on five human Cancer cell lines including Hep-G2 (hepatoma Cancer), KB (epidermoid carcinoma), LNCaP (prostate Cancer), MCF7 (breast Cancer), and SK-Mel2 (melanoma). Compounds 1-7 showed potent cytotoxicity on five tested Cancer cell lines with IC50 values ranging from 0.03 ± 0.01 to 7.36 ± 0.46 μM. With respect to the potent cytotoxicity of the isolated saponins, further studies are required to confirm efficacy in vivo and the mechanism of cytotoxic effects.

Keywords

Cercodemas anceps; Cercodemasoide; Cucumariidae; Cytotoxic activity; Sea cucumber.

Figures