2. Academic Validation
  3. New phenolic compounds from the seeds of Nigella glandulifera and their inhibitory activities against human cancer cells

New phenolic compounds from the seeds of Nigella glandulifera and their inhibitory activities against human cancer cells

  • Bioorg Med Chem Lett. 2015 Sep 15;25(18):3864-6. doi: 10.1016/j.bmcl.2015.07.055.
Lu Sun 1,  Yu-Ming Liu 2,  Bao-Quan Chen 1,  Qing-Hua Liu 3
Affiliations

Affiliations

  • 1 Department of Pharmacy Engineering, Tianjin University of Technology, Tianjin 300384, PR China.
  • 2 Department of Pharmacy Engineering, Tianjin University of Technology, Tianjin 300384, PR China. Electronic address: coumarin1968@hotmail.com.
  • 3 Xinjiang Institute of Materia Medica, Ürümuqi 830001, PR China.
PMID: 26227777 DOI: 10.1016/j.bmcl.2015.07.055
Abstract

Four phenolic compounds, including two new ones, Nigephenol A and B (1-2), and a new natural product, Nigephenol C (3), were isolated from the seeds of Nigella glandulifera. Their structures were elucidated on the basis of spectroscopic analyses using HR-ESI-MS, 1D and 2D NMR spectra. All compounds were evaluated by MTT method for in vitro cytotoxicity against four human Cancer cell lines (Bel7402, HepG2, HCT-8 and A549). The results revealed that Compounds 1-4 showed more selective activities against HepG2 cells, and that Compound 2 showed significant inhibitory effects against four human tumor cell lines with IC50 values comparable to those of 5-fluorouracil.

Keywords

Cytotoxic activity; Nigella; Nigella glandulifera; Phenolic compounds; Ranunculaceae.

Figures