2. Academic Validation
  3. The Effect of Etoricoxib on Hepatic Ischemia-Reperfusion Injury in Rats

The Effect of Etoricoxib on Hepatic Ischemia-Reperfusion Injury in Rats

  • Oxid Med Cell Longev. 2015;2015:598162. doi: 10.1155/2015/598162.
Celalettin Semih Kunak 1,  Osman Kukula 2,  Emre Mutlu 1,  Fatma Genç 3,  Gülçer Güleç Peker 4,  Ufuk Kuyrukluyıldız 5,  Orhan Binici 5,  Durdu Altuner 6,  Hamit Hakan Alp 7
Affiliations

Affiliations

  • 1 Department of Pharmacology, Faculty of Medicine, Ordu University, Ordu, Turkey.
  • 2 Department of Pharmacology, Faculty of Medicine, Ondokuz Mayıs University, Samsun, Turkey.
  • 3 Department of Pharmacology Nursery, Faculty of Health Science, Giresun University, Giresun, Turkey.
  • 4 Department of Medical Device and Drug Institute, Turkish Health Ministry, Ankara, Turkey.
  • 5 Department of Anesthesiology and Reanimation, Faculty of Medicine, Erzincan University, 24030 Erzincan, Turkey.
  • 6 Department of Pharmacology, Faculty of Medicine, Erzincan University, 24030 Erzincan, Turkey.
  • 7 Department of Biochemistry, Faculty of Medicine, 100 Yıl University, Van, Turkey.
PMID: 26236425 DOI: 10.1155/2015/598162
Abstract

Ischemia-reperfusion (I/R) damage is known to be a pathological process which continues with the increase of oxidants and expands with the inflammatory response. There is not any study about protective effect of etoricoxib on the liver I/R damage in literature.

Objective: This study investigates the effect of etoricoxib on oxidative stress induced by I/R of the rat liver.

Material and methods: Experimental Animals were divided into four groups as liver I/R control (LIRC), 50 mg/kg etoricoxib + liver I/R (ETO-50), 100 mg/kg etoricoxib + liver I/R (ETO-100), and healthy group (HG). ETO-50 and ETO-100 groups were administered etoricoxib, while LIRC and HG groups were orally given distilled water by gavage. Hepatic artery was clamped for one hour to provide ischemia, and then reperfusion was provided for 6 hours. Oxidant, antioxidant, and COX-2 gene expressions were studied in the liver tissues. ALT and AST were measured.

Results: Etoricoxib in 50 and 100 mg/kg doses changed the levels of oxidant/antioxidant parameters such as MDA, MPO, tGSH, GSHRd, GST, SOD, NO, and 8-OH/Gua in favour of antioxidants. Furthermore, etoricoxib prevented increase of COX-2 gene expression and ALT and AST levels. This important protective effect of etoricoxib on the rat liver I/R can be tested in the clinical setting.

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