Scapairrins A-Q, Labdane-Type Diterpenoids from the Chinese Liverwort Scapania irrigua and Their Cytotoxic Activity

J Nat Prod. 2015 Aug 28;78(8):2087-94. doi: 10.1021/acs.jnatprod.5b00416.

Jiaozhen Zhang ¹, Yi Li ¹, Rongxiu Zhu ², Lin Li ¹, Yongjie Wang ¹, Jinchuan Zhou ¹, Yanan Qiao ¹, Zhenwei Zhang ³, Hongxiang Lou ¹

Affiliations

1 Department of Natural Products Chemistry, Key Lab of Chemical Biology of the Ministry of Education, Shandong University , Jinan 250012, People's Republic of China.
2 School of Chemistry and Chemical Engineering, Shandong University , Jinan 250010, People's Republic of China.
3 School of Chemistry and Chemical Engineering, University of Jinan , Jinan 250022, People's Republic of China.

PMID: 26252628 DOI: 10.1021/acs.jnatprod.5b00416

Abstract

Seventeen new labdane-type Diterpenoids, scapairrins A-Q (1-17), including six pairs of diastereoisomers, and three known analogues (18-20) were isolated from the Chinese liverwort Scapania irrigua. The structures of 1-17 were determined based on a combination of the analysis of their MS and NMR spectroscopic data, single-crystal X-ray diffraction, and electronic circular dichroism calculations. Cytotoxicity testing showed that compounds 7-10 exhibited inhibitory activities against a small panel of human Cancer cell lines.

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