2. Academic Validation
  3. Carbon nanotubes supported tyrosinase in the synthesis of lipophilic hydroxytyrosol and dihydrocaffeoyl catechols with antiviral activity against DNA and RNA viruses

Carbon nanotubes supported tyrosinase in the synthesis of lipophilic hydroxytyrosol and dihydrocaffeoyl catechols with antiviral activity against DNA and RNA viruses

  • Bioorg Med Chem. 2015 Sep 1;23(17):5345-51. doi: 10.1016/j.bmc.2015.07.061.
Giorgia Botta 1,  Bruno Mattia Bizzarri 1,  Adriana Garozzo 2,  Rossella Timpanaro 2,  Benedetta Bisignano 2,  Donatella Amatore 3,  Anna Teresa Palamara 3,  Lucia Nencioni 4,  Raffaele Saladino 5
Affiliations

Affiliations

  • 1 Department of Ecology and Biology, University of Tuscia, Largo dell'Università, 01100 Viterbo (VT), Italy.
  • 2 Department of Biomedical and Biotechnological Sciences, Microbiological Section, University of Catania (CT), Via Androne, 81 95124 Catania, Italy.
  • 3 Department of Public Health and Infectious Diseases, 'Sapienza' University, 00185 Rome, Italy; IRCCS San Raffaele Pisana, Telematic University, 00166 Rome, Italy.
  • 4 Department of Public Health and Infectious Diseases, 'Sapienza' University, 00185 Rome, Italy.
  • 5 Department of Ecology and Biology, University of Tuscia, Largo dell'Università, 01100 Viterbo (VT), Italy. Electronic address: saladino@unitus.it.
PMID: 26260341 DOI: 10.1016/j.bmc.2015.07.061
Abstract

Hydroxytyrosol and dihydrocaffeoyl catechols with lipophilic properties have been synthesized in high yield using Tyrosinase immobilized on multi-walled carbon nanotubes by the Layer-by-Layer technique. All synthesized catechols were evaluated against a large panel of DNA and RNA viruses, including Poliovirus type 1, Echovirus type 9, Herpes simplex virus type 1 (HSV-1), Herpes simplex virus type 2 (HSV-2), Coxsackievirus type B3 (COX B3), Adenovirus type 2 and type 5 and Cytomegalovirus (CMV). A significant Antiviral activity was observed in the inhibition of HSV-1, HSV-2, COX B3 and CMV. The mechanism of action of the most active dihydrocaffeoyl derivative was investigated against a model of HSV-1 Infection.

Keywords

Antiviral activity; Catechols; DNA and RNA viruses; Dihydrocaffeoyl derivatives; Hydroxytyrosol derivatives.

Figures
Products