Discovery of novel isatin-dehydroepiandrosterone conjugates as potential anticancer agents

Bioorg Med Chem Lett. 2015 Oct 15;25(20):4628-31. doi: 10.1016/j.bmcl.2015.08.041.

Shaoyong Ke ¹, Liqiao Shi ², Ziwen Yang ²

Affiliations

1 National Biopesticide Engineering Research Center, Hubei Academy of Agricultural Sciences, Wuhan 430064, People's Republic of China. Electronic address: keshaoyong@163.com.
2 National Biopesticide Engineering Research Center, Hubei Academy of Agricultural Sciences, Wuhan 430064, People's Republic of China.

PMID: 26320625 DOI: 10.1016/j.bmcl.2015.08.041

Abstract

A series of isatin-dehydroepiandrosterone hybrids were synthesised via a convenient condensation procedure, and which were evaluated for their potential Anticancer activities. The preliminary assays indicated that some of the newly obtained compounds exhibited good antitumor activities against human hepatocellular liver carcinoma (HepG2), heptoma (Huh-7), melanoma (A875) and 5-fluorouracil-resistant human hepatocellular carcinoma (BEL-7402/5-FU) cell lines compared with 5-fluorouracil (5-FU), which might be considered as promising lead scaffold for further design and synthesis of highly potential Anticancer agents.

Keywords

Antitumor activity; Dehydroepiandrosterone; Hybrids; Isatin; Synthesis.

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