Systemic involvement in localized scleroderma/morphea

Clin Dermatol. 2015 Sep-Oct;33(5):556-62. doi: 10.1016/j.clindermatol.2015.05.009.

Anna Gorkiewicz-Petkow ¹, Agnieszka Kalinska-Bienias ²

Affiliations

1 Department of Dermatology and Immunodermatology, Medical University of Warsaw, Koszykowa 82 a str, 02-008 Warsaw, Poland.
2 Department of Dermatology and Immunodermatology, Medical University of Warsaw, Koszykowa 82 a str, 02-008 Warsaw, Poland. Electronic address: agnieszka.kalinska@interia.pl.

PMID: 26321403 DOI: 10.1016/j.clindermatol.2015.05.009

Abstract

Localized scleroderma (LoSc), also known as morphea, is a rare fibrosing disorder of the skin and underlying tissues. Sclerosis is mainly limited to the skin, but subcutaneous tissue, fascia, and underlying muscles and bone may also be involved. In some cases, systemic manifestation with visceral abnormalities may occur. Several publications have focused on significant aspects of LoSc: genetics, immunity, epidemiology, scoring systems, and unification of classifications. Clinical studies featuring large cohorts with the disease published by various international study groups have been of great value in furthering the diagnostic and therapeutic management of LoSc.

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