neo-Clerodane Diterpenoids from Scutellaria barbata and Their Inhibitory Effects on LPS-Induced Nitric Oxide Production

J Nat Prod. 2015 Sep 25;78(9):2292-6. doi: 10.1021/acs.jnatprod.5b00126.

Eung Tae Yeon ¹, Jin Woo Lee ¹, Chul Lee ¹, Qinghao Jin ¹, Hari Jang ¹, Dongho Lee ², Jong Seog Ahn ³, Jin Tae Hong ¹, Youngsoo Kim ¹, Mi Kyeong Lee ¹, Bang Yeon Hwang ¹

Affiliations

1 College of Pharmacy, Chungbuk National University , Cheongju 28644, Korea.
2 Department of Biosystems and Biotechnology, College of Life Sciences and Biotechnology, Korea University , Seoul 02841, Korea.
3 Korea Research Institute of Bioscience and Biotechnology , Cheongju 28116, Korea.

PMID: 26331882 DOI: 10.1021/acs.jnatprod.5b00126

Abstract

Three new neo-clerodane Diterpenoids (1-3) along with 12 known compounds (4-15) were isolated from a methanol extract of the aerial parts of Scutellaria barbata. The structures of 1-3 were determined by interpretation of their 1D and 2D NMR spectroscopic data as well as HRESIMS values. All isolated compounds were tested for their inhibitory effects on LPS-induced nitric oxide production in RAW 264.7 macrophages. Compounds 1-4, 7, and 10-12 were found to inhibit nitric oxide production with IC50 values ranging from 20.2 to 35.6 μM.

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