Streptozotocin-Induced Diabetic Models in Mice and Rats

Streptozotocin (STZ) is an Antibiotic that produces pancreatic islet β-cell destruction and is widely used experimentally to produce a model of type 1 diabetes mellitus (T1DM). Detailed in this unit are protocols for producing STZ-induced Insulin deficiency and hyperglycemia in mice and rats. Also described are protocols for creating animal models for type 2 diabetes using STZ. These Animals are employed for assessing the pathological consequences of diabetes and for screening potential therapies for the treatment of this condition.

high-fat; hyperglycemia; insulin deficiency; insulin resistance; insulitis; mouse or rat; nicotinamide; streptozotocin; type 1 diabetes mellitus; type 2 diabetes mellitus.