2. Academic Validation
  3. Anti-inflammatory Labdane Diterpenoids from Leonurus macranthus

Anti-inflammatory Labdane Diterpenoids from Leonurus macranthus

  • J Nat Prod. 2015 Sep 25;78(9):2276-85. doi: 10.1021/acs.jnatprod.5b00635.
Zheng Huang 1 2,  Zhi-Xiang Zhu 1,  Yue-Ting Li 1 2,  Dao-Ran Pang 1 2,  Jiao Zheng 1,  Qian Zhang 1,  Yun-Fang Zhao 1,  Daneel Ferreira 3,  Jordan K Zjawiony 3,  Peng-Fei Tu 1,  Jun Li 1
Affiliations

Affiliations

  • 1 Modern Research Center for Traditional Chinese Medicine, Beijing University of Chinese Medicine , Beijing 100029, People's Republic of China.
  • 2 School of Chinese Materia Medica, Beijing University of Chinese Medicine , Beijing 100102, People's Republic of China.
  • 3 Department of BioMolecular Sciences, Division of Pharmacognosy, and Research Institute of Pharmaceutical Sciences, School of Pharmacy, University of Mississippi , University, Mississippi 38677-1848, United States.
PMID: 26348503 DOI: 10.1021/acs.jnatprod.5b00635
Abstract

Twenty new polyoxygenated labdane Diterpenoids (1-20) were isolated from the aerial parts of Leonurus macranthus. Their structures were elucidated on the basis of spectroscopic and spectrometric data (1D and 2D NMR, IR, and HRESIMS). The absolute configurations of macranthin A (1) and 6-O-deacetylmacranthin A (2) were determined by single-crystal X-ray crystallographic analysis and a modified Mosher's method, respectively. Compounds 1-9, 12, 14, and 19 showed inhibition of nitric oxide production in lipopolysaccharide-activated BV-2 microglial cells with IC50 values of 10.0-63.7 μM.

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