Cytotoxic labdane-type diterpenes from Hedychium longipetalum inhibiting production of nitric oxide

Bioorg Med Chem Lett. 2015 Oct 15;25(20):4572-5. doi: 10.1016/j.bmcl.2015.08.057.

Hongmei Zhao ¹, Guangzhi Zeng ², Simeng Zhao ², Junju Xu ³, Lingmei Kong ², Yan Li ², Ninghua Tan ², Shengchao Yang ⁴

Affiliations

1 Yunnan Research Center on Good Agricultural Practice for Dominant Chinese Medicinal Materials, Yunnan Agricultural University, Kunming 650201, PR China; School of Pharmacy, Yunnan University of Traditional Chinese Medicine, Kunming 650500, PR China.
2 State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, PR China.
3 Yunnan Research Center on Good Agricultural Practice for Dominant Chinese Medicinal Materials, Yunnan Agricultural University, Kunming 650201, PR China. Electronic address: junjuxu007@126.com.
4 Yunnan Research Center on Good Agricultural Practice for Dominant Chinese Medicinal Materials, Yunnan Agricultural University, Kunming 650201, PR China.

PMID: 26351042 DOI: 10.1016/j.bmcl.2015.08.057

Abstract

Three new labdane diterpenes, hedylongnoids A (1), B (2) and C (3), were isolated from the rhizomes of Hedychium longipetalum, together with three known ones yunnancoronarin A (4), hedyforrestin C (5) and hedyforrestin B (6). Their structures were established by spectroscopic analysis, including 2D-NMR spectroscopic techniques. Compounds 1-6 exhibited inhibitory effects against nitric oxide (NO) production in LPS and IFN-γ-induced RAW 264.7 murine macrophages with IC50 values ranging from 0.56 to 7.50 μg/ml, and 3-6 showed cytotoxicities against Cancer cell lines SGC-7901 and Hela with IC50 values ranging from 6.21 to 14.53 μg/ml and from 6.58 to 14.83 μg/ml, respectively.

Keywords

Cytotoxicity; Hedychium longipetalum; Inhibition of NO production; Labdane diterpenes; Zingiberaceae.

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