Tetramic Acids and Pyridone Alkaloids from the Endolichenic Fungus Tolypocladium cylindrosporum

J Nat Prod. 2015 Sep 25;78(9):2155-60. doi: 10.1021/np501018w.

Xiao-Bin Li ¹, Lin Li ¹, Rong-Xiu Zhu ², Wei Li ¹, Wen-Qiang Chang ¹, Lu-Lu Zhang ³, Xiao-Ning Wang ¹, Zun-Tian Zhao ³, Hong-Xiang Lou ¹

Affiliations

1 Department of Natural Product Chemistry, Key Lab of Chemical Biology of Ministry of Education, School of Pharmaceutical Sciences, Shandong University , 44 Wenhua West Road, Jinan 250012, People's Republic of China.
2 School of Chemistry and Chemical Engineering, Shandong University , 27 Shanda Nanlu, Jinan 250100, People's Republic of China.
3 College of Life Sciences, Shandong Normal University , 88 Wenhua East Road, Jinan 250014, People's Republic of China.

PMID: 26356746 DOI: 10.1021/np501018w

Abstract

Three new tetramic acid derivatives, tolypocladenols A1, A2, and B (1-3), a new pyridone alkaloid, tolypyridone A (4), and a new coumarin derivative, 3,8-dihydroxy-4-(4-hydroxyphenyl)-6-methylcoumarin (5), together with four known compounds (6-9) were isolated from the endolichenic fungus Tolypocladium cylindrosporum, which inhabits the Lichen Lethariella zahlbruckneri. Structures of these compounds were determined by comprehensive analysis of spectroscopic data and single-crystal X-ray diffraction determination. Bioassay of the isolated compounds found that pyridoxatin (7) was cytotoxic to human Cancer cells by induction of G0/G1 cell cycle arrest and Apoptosis.

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