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  3. Synthesis and pharmacological evaluation of some new fluorine containing hydroxypyrazolines as potential anticancer and antioxidant agents

Synthesis and pharmacological evaluation of some new fluorine containing hydroxypyrazolines as potential anticancer and antioxidant agents

  • Eur J Med Chem. 2015 Nov 2:104:25-32. doi: 10.1016/j.ejmech.2015.09.029.
Dinesha 1,  Shivapura Viveka 1,  Bolli Keerthi Priya 2,  K Sreedhara Ranganath Pai 2,  Shivalingegowda Naveen 3,  Neratur K Lokanath 4,  Gundibasappa Karikannar Nagaraja 5
Affiliations

Affiliations

  • 1 Department of Studies in Chemistry, Mangalore University, Mangalagangotri 574 199, India.
  • 2 Manipal College of Pharmaceutical Sciences, Manipal University, Manipal 576 104, India.
  • 3 Institution of Excellence, Vijnana Bhavana, University of Mysore, Mysore 570 006, India.
  • 4 Department of Studies in Physics, University of Mysore, Mysore 570 006, India.
  • 5 Department of Studies in Chemistry, Mangalore University, Mangalagangotri 574 199, India. Electronic address: nagarajagk@gmail.com.
PMID: 26433616 DOI: 10.1016/j.ejmech.2015.09.029
Abstract

Breast Cancer is probably the most prevalent Cancer in women. The development of resistance to therapeutic agents and lack of targeted therapy for breast Cancer cells provide motivation to identify new compounds for the treatment. With this objective in mind, a new series of 3-fluoro-4-methoxyphenyl group based 1,3,5-trisubstituted aryl-5-hydroxypyrazoline analogues 4a-l was synthesized through multi-step reaction sequence. The structures of the newly synthesized compounds were confirmed by IR, (1)H NMR, (13)C NMR, LC-MS and elemental analysis. They were screened for their in vitro Anticancer and in vitro antioxidant activities. Among the tested compounds 4h, 4c and particularly 4i displayed promising cytotoxic effect on breast Cancer cell lines. The compounds were also found to possess antioxidant activity when tested against DPPH free radical. Overall, this work has contributed to the development of promising leads for Anticancer and antioxidant activities.

Keywords

Anticancer activity; Antioxidant activity; Characterization; Hydroxypyrazolines; Synthesis.

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