2. Academic Validation
  3. Anti-inflammatory Inositol Derivatives from the Whole Plant of Inula cappa

Anti-inflammatory Inositol Derivatives from the Whole Plant of Inula cappa

  • J Nat Prod. 2015 Oct 23;78(10):2332-8. doi: 10.1021/acs.jnatprod.5b00135.
Jiewei Wu 1,  Chunping Tang 1,  Sheng Yao 1,  Lei Zhang,  Changqiang Ke 1,  Linyin Feng,  Ge Lin 1 2,  Yang Ye 1 3
Affiliations

Affiliations

  • 1 Joint Research Laboratory for Promoting Globalization of Traditional Chinese Medicines between Shanghai Institute of Materia Medica, Chinese Academy of Sciences and The Chinese University of Hong Kong , Hong Kong, People's Republic of China.
  • 2 School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong , Shatin, NT, Hong Kong, SAR, People's Republic of China.
  • 3 School of Life Science and Technology, ShanghaiTech University , Shanghai 201203, People's Republic of China.
PMID: 26444098 DOI: 10.1021/acs.jnatprod.5b00135
Abstract

Twelve new inositol derivatives, classified into myoinositol (1-6) and l-inositol (10-15) types, along with five known analogues were isolated from the whole plant of Inula cappa. The structures of the new compounds were established by extensive analysis of mass spectrometric and 1D and 2D NMR spectroscopic data. All the tested compounds showed anti-inflammatory activities against the production of NO in RAW264.7 macrophages stimulated by lipopolysaccharide, with IC50 values ranging from 7 to 23 μM.

Figures