2. Academic Validation
  3. Antibacterial activity of cyclo(L-Pro-L-Tyr) and cyclo(D-Pro-L-Tyr) from Streptomyces sp. strain 22-4 against phytopathogenic bacteria

Antibacterial activity of cyclo(L-Pro-L-Tyr) and cyclo(D-Pro-L-Tyr) from Streptomyces sp. strain 22-4 against phytopathogenic bacteria

  • Nat Prod Res. 2016 Sep;30(17):1980-3. doi: 10.1080/14786419.2015.1095747.
Pakorn Wattana-Amorn 1,  Waranya Charoenwongsa 1,  Christopher Williams 2,  Matthew P Crump 2,  Busaya Apichaisataienchote 3
Affiliations

Affiliations

  • 1 a Faculty of Science, Department of Chemistry, Center of Excellence for Innovation in Chemistry and Special Research Unit for Advanced Magnetic Resonance , Kasetsart University , Bangkok , Thailand.
  • 2 b School of Chemistry , University of Bristol , Bristol , United Kingdom.
  • 3 c Faculty of Engineering and Industrial Technology, Department of Biotechnology , Silpakorn University , Nakhon Pathom , Thailand.
PMID: 26469746 DOI: 10.1080/14786419.2015.1095747
Abstract

Two bioactive cyclic dipeptides, cyclo(L-Pro-L-Tyr) and cyclo(D-Pro-L-Tyr), were isolated from the culture broth of Streptomyces sp. strain 22-4 and tested against three economically important plant pathogens, Xanthomonas axonopodis pv. citri, Ralstonia solanacearum and Clavibacter michiganensis. Both cyclic dipeptides were active against X. axonopodis pv. citri and R. Solanacearum with MIC of 31.25 μg/mL. No activity could be observed against C. michiganensis.

Keywords

Cyclo(L-Pro-L-Tyr); Streptomyces; cyclo(D-Pro-L-Tyr); phytopathogenic bacteria.

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