2. Academic Validation
  3. Synthesis of triphenylphosphonium vitamin E derivatives as mitochondria-targeted antioxidants

Synthesis of triphenylphosphonium vitamin E derivatives as mitochondria-targeted antioxidants

  • Tetrahedron. 2015 Nov 4;71(44):8444-8453. doi: 10.1016/j.tet.2015.09.014.
Victoria J A Jameson 1,  Helena M Cochemé 2,  Angela Logan 3,  Lyall R Hanton 1,  Robin A J Smith 1,  Michael P Murphy 3
Affiliations

Affiliations

  • 1 Department of Chemistry, University of Otago, PO Box 56, Dunedin, 9054, New Zealand.
  • 2 MRC Clinical Sciences Centre, Imperial College, London, W12 0NN, UK ; MRC Mitochondrial Biology Unit, Hills Road, Cambridge, CB2 0XY, UK.
  • 3 MRC Mitochondrial Biology Unit, Hills Road, Cambridge, CB2 0XY, UK.
PMID: 26549895 DOI: 10.1016/j.tet.2015.09.014
Abstract

A series of mitochondria-targeted antioxidants comprising a lipophilic triphenylphosphonium cation attached to the antioxidant chroman moiety of vitamin E by an alkyl linker have been prepared. The synthesis of a series of mitochondria-targeted vitamin E derivatives with a range of alkyl linkers gave compounds of different hydrophobicities. This work will enable the dependence of antioxidant defence on hydrophobicity to be determined in vivo.

Keywords

Lipid peroxidation; MitoE; Mitochondria; Mitochondria-targeted antioxidant; Vitamin E.

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