2. Academic Validation
  3. Alkaloids with Different Carbon Units from Myrioneuron faberi

Alkaloids with Different Carbon Units from Myrioneuron faberi

  • J Nat Prod. 2015 Nov 25;78(11):2609-16. doi: 10.1021/acs.jnatprod.5b00543.
Ming-Ming Cao 1 2,  Yu Zhang 1,  Sheng-Dian Huang 1,  Ying-Tong Di 1,  Zong-Gen Peng 3,  Jian-Dong Jiang 3,  Chun-Mao Yuan 1,  Duo-Zhi Chen 1,  Shun-Lin Li 1,  Hong-Ping He 1,  Xiao-Jiang Hao 1
Affiliations

Affiliations

  • 1 State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences , Kunming 650201, Yunnan, People's Republic of China.
  • 2 College of Food Science and Technology, Nanjing Agricultural University , Nanjing 210095, Jiangsu, People's Republic of China.
  • 3 Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing 10050, People's Republic of China.
PMID: 26551513 DOI: 10.1021/acs.jnatprod.5b00543
Abstract

Three new Myrioneuron Alkaloids, myrifamines A-C (1-3), with unique skeletons were isolated from Myrioneuron faberi. The absolute configuration of 1 was confirmed by single-crystal X-ray diffraction analysis, and the stereochemistry of the Other two Alkaloids was determined using a combination of ROESY experiments and calculated and experimental electronic circular dichroism spectra. Myrifamine C (3) is the first example of a symmetric dimer among the Myrioneuron Alkaloids. Known Alkaloids myrionamide (4) and schoberine (5) were also isolated, and experimental NMR and X-ray diffraction data suggest their structural revision. Compound 2 showed significant inhibitory activity toward the hepatitis C virus in vitro, with a therapeutic index (CC50/EC50) greater than 108.7.

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