2. Academic Validation
  3. Cytotoxic Orbitide from the Latex of Croton urucurana

Cytotoxic Orbitide from the Latex of Croton urucurana

  • J Nat Prod. 2015 Nov 25;78(11):2754-60. doi: 10.1021/acs.jnatprod.5b00724.
Priscila de M Cândido-Bacani 1 2,  Patrícia de O Figueiredo 1,  Maria de F C Matos 2,  Fernanda R Garcez 1,  Walmir S Garcez 1
Affiliations

Affiliations

  • 1 Instituto de Química, Universidade Federal de Mato Grosso do Sul , Campo Grande, MS 79074-460, Brazil.
  • 2 Centro de Ciências Biológicas e da Saúde, Universidade Federal de Mato Grosso do Sul , Campo Grande, MS 79070-900, Brazil.
PMID: 26561866 DOI: 10.1021/acs.jnatprod.5b00724
Abstract

The bioactive ethyl acetate phase obtained from the latex of Croton urucurana Baillon afforded a novel orbitide (1), [1-9-NαC]-crourorb A1, that proved active against NCI-ADR/RES (ovary, multidrug-resistance phenotype) cells with the same potency as doxorubicin (positive control) and inactive up to the highest concentration tested against nontumor NIH/3T3 cells. The structure elucidation was based on 1D and 2D NMR spectroscopy, further supported by HRESIMS data and by application of Marfey's method for determination of the absolute configuration of its amino acid residues. This is the first orbitide obtained from C. urucurana.

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