2. Academic Validation
  3. Chemical Constituents from the Fruiting Bodies of Hexagonia apiaria and Their Anti-inflammatory Activity

Chemical Constituents from the Fruiting Bodies of Hexagonia apiaria and Their Anti-inflammatory Activity

  • J Nat Prod. 2015 Nov 25;78(11):2552-8. doi: 10.1021/acs.jnatprod.5b00449.
Tran Dinh Thang 1,  Ping-Chung Kuo 2,  Nguyen Thi Bich Ngoc 1,  Tsong-Long Hwang 3 4,  Mei-Lin Yang 2,  Shih-Huang Ta 5,  E-Jian Lee 5,  Dai-Huang Kuo 6,  Nguyen Huy Hung 1,  Nguyen Ngoc Tuan 1,  Tian-Shung Wu 6 7
Affiliations

Affiliations

  • 1 Department of Chemistry, Vinh University , Vinh City 42000, Vietnam.
  • 2 Department of Biotechnology, National Formosa University , Yunlin 63201, Taiwan, ROC.
  • 3 Graduate Institute of Natural Products, Chang Gung University , Taoyuan 33302, Taiwan, ROC.
  • 4 Chinese Herbal Medicine Research Team, Healthy Aging Research Center, Chang Gung University , Taoyuan 33302, Taiwan, ROC.
  • 5 Neurosurgical Service, Department of Surgery, National Cheng Kung Medical Center and Medical School , Tainan, Taiwan, ROC.
  • 6 Department of Pharmacy and Graduate Institute of Pharmaceutical Technology, Tajen University , Pingtung 90741, Taiwan, ROC.
  • 7 School of Pharmacy, National Cheng Kung University , Tainan 70101, Taiwan, ROC.
PMID: 26575215 DOI: 10.1021/acs.jnatprod.5b00449
Abstract

A chemical investigation of the fruiting bodies of Hexagonia apiaria resulted in the identification of nine compounds including five new triterpenoids, hexagonins A-E (1-5), along with four known compounds. The purified constituents were examined for their anti-inflammatory activity. Among the tested compounds, hexatenuin A displayed the most significant inhibition of superoxide anion generation and Elastase release. These triterpenoids may have potentials as anti-inflammatory agents.

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