2. Academic Validation
  3. Picrajavanicins A-G, Quassinoids from Picrasma javanica Collected in Myanmar

Picrajavanicins A-G, Quassinoids from Picrasma javanica Collected in Myanmar

  • J Nat Prod. 2015 Dec 24;78(12):3024-30. doi: 10.1021/acs.jnatprod.5b00824.
Nwet Nwet Win 1 2,  Takuya Ito 1,  Ismail 3,  Takeshi Kodama 1,  Yi Yi Win 2,  Masami Tanaka 4,  Hla Ngwe 2,  Yoshinori Asakawa 4,  Ikuro Abe 5,  Hiroyuki Morita 1
Affiliations

Affiliations

  • 1 Institute of Natural Medicine, University of Toyama , 2630-Sugitani, Toyama 930-0194, Japan.
  • 2 Department of Chemistry, University of Yangon , Yangon 11041, Myanmar.
  • 3 Faculty of Pharmacy, Hasanuddin University , Makassar 90245, South Sulawesi, Indonesia.
  • 4 Faculty of Pharmaceutical Sciences, Tokushima Bunri University , Yamashiro-cho, Tokushima 770-8514, Japan.
  • 5 Graduate School of Pharmaceutical Sciences, The University of Tokyo , 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
PMID: 26606140 DOI: 10.1021/acs.jnatprod.5b00824
Abstract

Seven new tetracyclic quassinoids, picrajavanicins A-G (1-7), along with three known analogues, were isolated from a CHCl3-soluble extract of the bark of Picrasma javanica collected in Myanmar. The structures of these compounds were elucidated using spectroscopic techniques, including 1D and 2D NMR. The absolute configuration at C-2 of 2 was determined to be S by the modified Mosher method. All the isolates were tested for their antiproliferative activities against a small panel of five human Cancer cell lines. However, none of the isolated compounds exhibited inhibitory activity against any of the Cancer cells used (IC50 values >10 μM).

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