ent-Abietane-type diterpenoids from the roots of Euphorbia ebracteolata with their inhibitory activities on LPS-induced NO production in RAW 264.7 macrophages

Bioorg Med Chem Lett. 2016 Jan 1;26(1):1-5. doi: 10.1016/j.bmcl.2015.11.080.

Zhi-guo Liu ¹, Zhan-lin Li ¹, Da-Hong Li ¹, Ning Li ¹, Jiao Bai ¹, Feng Zhao ², Da-li Meng ³, Hui-ming Hua ⁴

Affiliations

1 Department of Natural Products Chemistry, Shenyang Pharmaceutical University, Shenyang 110016, PR China; Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, PR China.
2 School of Pharmacy, Yantai University, Yantai 264005, PR China.
3 Department of Natural Products Chemistry, Shenyang Pharmaceutical University, Shenyang 110016, PR China; Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, PR China. Electronic address: mengdl@163.com.
4 Department of Natural Products Chemistry, Shenyang Pharmaceutical University, Shenyang 110016, PR China; Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, PR China. Electronic address: huimhua@163.com.

PMID: 26615888 DOI: 10.1016/j.bmcl.2015.11.080

Abstract

Ten ent-abietane Diterpenoids (1-10), including four new (1-4) and six known ones (5-10) were isolated from the roots of Euphorbia ebracteolata. Their structures were determined by 1D, 2D NMR, and HRESIMS. Compounds 2, 4, and 7 exhibited significant inhibitory activities on lipopolysaccharide (LPS)-induced nitric oxide production in RAW 264.7 macrophages with IC50 values of 0.69, 1.97, and 0.88μM, respectively. A primary structure-activity relationship was also discussed.

Keywords

Anti-inflammation; Ent-abietane diterpenoids; Euphorbia ebracteolata.

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