2. Academic Validation
  3. Isolation of bioactive biphenyl compounds from the twigs of Chaenomeles sinensis

Isolation of bioactive biphenyl compounds from the twigs of Chaenomeles sinensis

  • Bioorg Med Chem Lett. 2016 Jan 15;26(2):351-354. doi: 10.1016/j.bmcl.2015.12.004.
Chung Sub Kim 1,  Lalita Subedi 2,  Oh Kil Kwon 1,  Sun Yeou Kim 2,  Eui-Ju Yeo 3,  Sang Un Choi 4,  Kang Ro Lee 5
Affiliations

Affiliations

  • 1 Natural Products Laboratory, School of Pharmacy, Sungkyunkwan University, 2066 Seobu-ro, Jangan-gu, Suwon 16419, Republic of Korea.
  • 2 Gachon Institute of Pharmaceutical Science, Gachon University, 191 Hambakmoero, Yeonsu-gu, Incheon 21936, Republic of Korea; College of Pharmacy, Gachon University, 191 Hambakmoero, Yeonsu-gu, Incheon 21936, Republic of Korea.
  • 3 Department of Biochemistry, College of Medicine, Gachon University, 191 Hambakmoero, Yeonsu-gu, Incheon 51936, Republic of Korea.
  • 4 Korea Research Institute of Chemical Technology, Daejeon 34114, Republic of Korea.
  • 5 Natural Products Laboratory, School of Pharmacy, Sungkyunkwan University, 2066 Seobu-ro, Jangan-gu, Suwon 16419, Republic of Korea. Electronic address: krlee@skku.edu.
PMID: 26706168 DOI: 10.1016/j.bmcl.2015.12.004
Abstract

Investigation of the MeOH extract of Chaenomeles sinensis twigs resulted in the isolation of seven biphenyl compounds (1-7) including a new compound, chaenomin (1). The chemical structures of the isolated compounds were elucidated by extensive NMR data ((1)H and (13)C NMR, (1)H-(1)H COSY, HSQC and HMBC), specific optical rotation, and chemical reaction. Compounds 2 and 6 showed potent cytotoxic activities against four Cancer cell lines (A549, SK-OV-3, SK-MEL-2, and HCT15), and compound 7 exhibited potent anti-neuroinflammatory and NGF-potentiating activity.

Keywords

Anti-inflammation; Biphenyl compounds; Chaenomeles sinensis; Cytotoxicity; NGF-potentiation.

Figures