The Medicinal Chemistry of Dengue Virus

J Med Chem. 2016 Jun 23;59(12):5622-49. doi: 10.1021/acs.jmedchem.5b01653.

Mira A M Behnam ¹, Christoph Nitsche ¹, Veaceslav Boldescu ¹ ², Christian D Klein ¹

Affiliations

1 Medicinal Chemistry, Institute of Pharmacy and Molecular Biotechnology IPMB, Heidelberg University , Im Neuenheimer Feld 364, 69120 Heidelberg, Germany.
2 Laboratory of Organic Synthesis, Institute of Chemistry of the Academy of Sciences of Moldova , Academiei 3, 2028 Chisinau, Moldova.

PMID: 26771861 DOI: 10.1021/acs.jmedchem.5b01653

Abstract

The Dengue virus and related flaviviruses are an increasing global health threat. In this perspective, we comment on and review medicinal chemistry efforts aimed at the prevention or treatment of dengue infections. We include target-based approaches aimed at viral or host factors and results from phenotypic screenings in cellular assay systems for viral replication. This perspective is limited to the discussion of results that provide explicit chemistry or structure-activity relationship (SAR), or appear to be of particular interest to the medicinal chemist for Other reasons. The discovery and development efforts discussed here may at least partially be extrapolated toward Other emerging flaviviral infections, such as West Nile virus. Therefore, this perspective, although not aimed at flaviviruses in general, should also be able to provide an overview of the medicinal chemistry of these closely related infectious agents.

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