Diterpenes from the Trunk of Abies holophylla and Their Potential Neuroprotective and Anti-inflammatory Activities

J Nat Prod. 2016 Feb 26;79(2):387-94. doi: 10.1021/acs.jnatprod.5b01053.

Chung Sub Kim ¹, Lalita Subedi ² ³, Sun Yeou Kim ² ³, Sang Un Choi ⁴, Ki Hyun Kim ¹, Kang Ro Lee ¹

Affiliations

1 Natural Products Laboratory, School of Pharmacy, Sungkyunkwan University , Suwon 16419, Republic of Korea.
2 Gachon Institute of Pharmaceutical Science, Gachon University , Incheon 21936, Republic of Korea.
3 College of Pharmacy, Gachon University , #191, Hambakmoero, Yeonsu-gu, Incheon 21936, Republic of Korea.
4 Korea Research Institute of Chemical Technology , Daejeon 34114, Republic of Korea.

PMID: 26812172 DOI: 10.1021/acs.jnatprod.5b01053

Abstract

Eleven new abietane-type diterpenes, holophyllins D-N (1-11), and 17 known analogues (12-28), were isolated from a MeOH extract of the trunk of Abies holophylla. The chemical structures of 1-11 were determined through spectroscopic data analysis, including NMR ((1)H and (13)C NMR, DEPT, (1)H-(1)H COSY, HMQC, HMBC, and NOESY) and HRFABMS methods. All isolated compounds (1-28) were evaluated for their cytotoxicity against four human tumor cell lines (A549, SK-OV-3, SK-MEL-2, and HCT-116), for their potential neuroprotective effects through induction of nerve growth factor in C6 glioma cells, and for their effects on nitric oxide levels in lipopolysaccharide-stimulated murine microglia BV2 cells.

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