2. Academic Validation
  3. A unique macrolactam derivative via a [4+6]-cycloaddition from Streptomyces niveus

A unique macrolactam derivative via a [4+6]-cycloaddition from Streptomyces niveus

  • Bioorg Med Chem Lett. 2016 Mar 15;26(6):1599-1604. doi: 10.1016/j.bmcl.2016.02.002.
Liya Li 1,  Yaping Cai 1,  Yi Jiang 2,  Jiang Liu 1,  Jian Ma 1,  Chunhui Yuan 1,  Yu Mu 1,  Li Han 3,  Xueshi Huang 1
Affiliations

Affiliations

  • 1 Institute of Microbial Pharmaceuticals, College of Life and Health Sciences, Northeastern University, Shenyang 110819, PR China.
  • 2 Yunnan Institute of Microbiology, Yunnan University, Kunming 650091, PR China.
  • 3 Institute of Microbial Pharmaceuticals, College of Life and Health Sciences, Northeastern University, Shenyang 110819, PR China. Electronic address: hanli@mail.neu.edu.cn.
PMID: 26874404 DOI: 10.1016/j.bmcl.2016.02.002
Abstract

One new macrolactam derivative, nivelactam (1) and one new polyenoic acid derivative, niveamide (2), along with two Other known 20-atom macrolactams (3 and 4) were isolated from the fermentation broth of Streptomyces niveus, which obtained from the forest soil in northeastern China. The structures of 1 and 2 were elucidated on the basis of HRESIMS, IR, and NMR spectroscopic data analyses. Compound 1 was proposed as an intramolecular [4+6]-cycloaddition product of 3 by S. niveus, and displayed moderate cytotoxic activity against a panel of human tumor cell lines in vitro, with IC50 values ranging from 3.76 ± 0.58 to 15.02 ± 2.81 μM.

Keywords

Cycloaddition; Cytotoxicity; In vitro; Macrolactam; Streptomyces niveus.

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