2. Academic Validation
  3. Rubiaceae-Type Cyclopeptides from Galianthe thalictroides

Rubiaceae-Type Cyclopeptides from Galianthe thalictroides

  • J Nat Prod. 2016 Apr 22;79(4):1165-9. doi: 10.1021/acs.jnatprod.5b00849.
Patrícia O Figueiredo 1,  Maria de Fatima C Matos 2,  Renata T Perdomo 2,  Wilson H Kato Jr 1,  Marcos Vinícius G O Barros 1,  Fernanda R Garcez 1,  Walmir S Garcez 1
Affiliations

Affiliations

  • 1 Instituto de Química, Universidade Federal de Mato Grosso do Sul , Campo Grande, MS 79074-460, Brazil.
  • 2 Centro de Ciências Biológicas e da Saúde, Universidade Federal de Mato Grosso do Sul , Campo Grande, MS 79070-900, Brazil.
PMID: 26913941 DOI: 10.1021/acs.jnatprod.5b00849
Abstract

Two Rubiaceae-type Cyclopeptides, 6-O-methylbouvardin (1) and the new cyclopeptide 5β-hydroxy-RA-III (2), were isolated from the roots of Galianthe thalictroides. Employing the sulforhodamine B assay, compounds 1 and 2 were tested in vitro against three Cancer cell lines--786-0 (kidney carcinoma), PC-3 (prostate carcinoma), and HT-29 (colon carcinoma)--and showed GI50 values ranging from 0.06 to 1.80 μg mL(-1). This is the first report on the isolation of Rubiaceae-type Cyclopeptides from a genus Other than Rubia or Bouvardia.

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