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  3. Anticancer activity studies of cubebin isolated from Piper cubeba and its synthetic derivatives

Anticancer activity studies of cubebin isolated from Piper cubeba and its synthetic derivatives

  • Bioorg Med Chem Lett. 2016 Apr 1;26(7):1767-71. doi: 10.1016/j.bmcl.2016.02.041.
Dhanya S Rajalekshmi 1,  Farha A Kabeer 2,  Arya R Madhusoodhanan 3,  Arun K Bahulayan 4,  Remani Prathapan 2,  Nisha Prakasan 4,  Sunil Varughese 3,  Mangalam S Nair 5
Affiliations

Affiliations

  • 1 Chemical Sciences and Technology Division, CSIR-National Institute for Interdisciplinary Science and Technology, Thiruvananthapuram 695019, Kerala, India; Academy of Scientific and Innovative Research (AcSIR), CSIR-NIIST, Thiruvananthapuram 695019, Kerala, India.
  • 2 Division of Cancer Research, Regional Cancer Centre, Thiruvananthapuram, Kerala, India.
  • 3 Chemical Sciences and Technology Division, CSIR-National Institute for Interdisciplinary Science and Technology, Thiruvananthapuram 695019, Kerala, India.
  • 4 Agroprocessing and Natural Products Division, CSIR-National Institute for Interdisciplinary Science and Technology, Thiruvananthapuram 695019, Kerala, India.
  • 5 Chemical Sciences and Technology Division, CSIR-National Institute for Interdisciplinary Science and Technology, Thiruvananthapuram 695019, Kerala, India; Academy of Scientific and Innovative Research (AcSIR), CSIR-NIIST, Thiruvananthapuram 695019, Kerala, India. Electronic address: msn555in@yahoo.co.in.
PMID: 26916436 DOI: 10.1016/j.bmcl.2016.02.041
Abstract

(-)-Cubebin, isolated from the seeds of Piper cubeba, and its five different types of derivatives (a total of 17), with varying functionalities, were tested for their in vitro Anticancer activity against six human Cancer cell lines (A549, K562, SiHa, KB, HCT116 and HT29) using MTT assay. Cubebin as well as its derivatives containing lactone and amide groups showed significant Anticancer activity. In some of the tested cell lines, the amide derivatives showed higher activity. Morphological analysis indicated that these compounds act through Apoptosis mediated pathway of cell death and we expect that these results will pave new paths in the development of novel Anticancer agents by the derivatization of (-)-cubebin.

Keywords

Amide derivatives; Anticancer activity; Apoptosis; Cubebin; Hinokinin; Morphological analysis.

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