2. Academic Validation
  3. New cytotoxic neo-clerodane diterpenoids from Scutellaria strigillosa

New cytotoxic neo-clerodane diterpenoids from Scutellaria strigillosa

  • Bioorg Med Chem Lett. 2016 Apr 1;26(7):1750-3. doi: 10.1016/j.bmcl.2016.02.045.
Sheng-Jun Dai 1,  Lei Zhang 2,  Kai Xiao 2,  Qing-Tong Han 2
Affiliations

Affiliations

  • 1 School of Pharmaceutical Science, Yantai University, Yantai 264005, PR China. Electronic address: daishengjun_9@hotmail.com.
  • 2 School of Pharmaceutical Science, Yantai University, Yantai 264005, PR China.
PMID: 26920801 DOI: 10.1016/j.bmcl.2016.02.045
Abstract

Three new neo-clerodane Diterpenoids, named scutestrigillosins A-C (1-3), were isolated from the whole plant of Scutellaria strigillosa. Their chemical structures including absolute configurations were established on the basis of detailed physical data analyses. In vitro, the isolated three new compounds exhibited significant cytotoxic activities against four tumor cell lines (HONE-1, P-388, MCF7 and HT29), and gave IC50 values in the range 3.5-7.7μM.

Keywords

Cytotoxic activity; Scutellaria strigillosa; Scutestrigillosins A–C; neo-Clerodane diterpenoid.

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