Bougainvinones A-H, Peltogynoids from the Stem Bark of Purple Bougainvillea spectabilis and Their Cytotoxic Activity

J Nat Prod. 2016 Apr 22;79(4):939-45. doi: 10.1021/acs.jnatprod.5b00996.

Lien T M Do ¹ ², Thammarat Aree ¹, Pongpun Siripong ³, Tuyen N K Pham ², Phung K P Nguyen ⁴, Santi Tip-Pyang ¹

Affiliations

1 Natural Products Research Unit, Department of Chemistry, Faculty of Science, Chulalongkorn University , Bangkok 10330, Thailand.
2 Sai Gon University , Ho Chi Minh City 748355, Vietnam.
3 Natural Products Research Section, Research Division, National Cancer Institute, Bangkok 10400, Thailand.
4 University of Science, National University - Ho Chi Minh City , Ho Chi Minh City 748355, Vietnam.

PMID: 26963142 DOI: 10.1021/acs.jnatprod.5b00996

Abstract

Eight new peltogynoids, named bougainvinones A-H (1-8), were obtained from the stem bark of Bougainvillea spectabilis. Their structures were elucidated by means of physical data (1D and 2D NMR, HRESIMS) and single-crystal X-ray crystallographic analyses. The peltogynoids, a rare type of modified Flavonoids, are reported for the first time from this species of the genus Bougainvillea. All isolated compounds were evaluated for their cytotoxic effects against five Cancer cell lines including KB, Hela S-3, HT-29, MCF-7, and HepG2. Among them, compound 7 showed cytotoxicity against five Cancer cell lines with IC50 values in the 7.4-9.7 μM range, and compounds 2 and 3 exhibited cytotoxicity against the KB cell line with IC50 values of 6.6 and 9.0 μM.

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