2. Academic Validation
  3. Astemizole Derivatives as Fluorescent Probes for hERG Potassium Channel Imaging

Astemizole Derivatives as Fluorescent Probes for hERG Potassium Channel Imaging

  • ACS Med Chem Lett. 2016 Jan 20;7(3):245-9. doi: 10.1021/acsmedchemlett.5b00360.
Beilei Wang 1,  Zhenzhen Liu 1,  Zhao Ma 1,  Minyong Li 1,  Lupei Du 1
Affiliations

Affiliation

  • 1 Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (MOE), School of Pharmacy, Shandong University , Jinan, Shandong 250012, China.
PMID: 26985309 DOI: 10.1021/acsmedchemlett.5b00360
Abstract

The detection and imaging of hERG potassium channels in living cells can provide useful information for hERG-correlation studies. Herein, three small-molecule fluorescent probes, based on the potent hERG channel inhibitor astemizole, for the imaging of hERG channels in hERG-transfected HEK293 cells (hERG-HEK293) and human colorectal Cancer cells (HT-29), are described. These probes are expected to be applied in the physiological and pathological studies of hERG channels.

Keywords

astemizole; cell imaging; fluorescent probes; hERG potassium channel.

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