Two novel phenanthraquinones with anti-cancer activity isolated from Bletilla striata

Bioorg Med Chem Lett. 2016 May 1;26(9):2375-9. doi: 10.1016/j.bmcl.2016.01.076.

Aijing Sun ¹, Jieqing Liu ², Suqiu Pang ¹, Junsheng Lin ², Ruian Xu ³

Affiliations

1 School of Biomedical Sciences, Huaqiao University, Quanzhou 362021, Fujian, China; Department of Clinical Pharmacy, The 180th Hospital of the People's Liberation Army, Quanzhou 362000, Fujian, China.
2 School of Biomedical Sciences, Huaqiao University, Quanzhou 362021, Fujian, China.
3 School of Biomedical Sciences, Huaqiao University, Quanzhou 362021, Fujian, China. Electronic address: ruianxu@hqu.edu.cn.

PMID: 26995526 DOI: 10.1016/j.bmcl.2016.01.076

Abstract

7-Hydroxy-2-methoxy-phenanthrene-3,4-dione and 3',7',7-trihydroxy-2,2',4'-trimethoxy-[1,8'-biphenanthrene]-3,4-dione, two novel compounds and four known compounds were isolated from Bletilla striata. The structures of the compounds were established on the basis of extensive spectroscopic analysis. The two compounds exhibited antiproliferative effects using the MTT test; these effects may be due to cell cycle arrest and inducing ROS generation.

Keywords

Anti-tumor activity; Bletilla striata; Cell cycle arrest; Phenanthraquinone; Reactive oxygen species.

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