2. Academic Validation
  3. A New Indole Alkaloid from the Toad Venom of Bufo bufo gargarizans

A New Indole Alkaloid from the Toad Venom of Bufo bufo gargarizans

  • Molecules. 2016 Mar 16;21(3):349. doi: 10.3390/molecules21030349.
Ying-Hui Dai 1,  Bo Shen 2,  Ming-Yu Xia 3,  An-Dong Wang 4,  Yu-Lin Chen 5,  Dong-Chun Liu 6 7,  Dong Wang 8 9
Affiliations

Affiliations

  • 1 School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, Liaoning, China. yhdai2008@aliyun.com.
  • 2 School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, Liaoning, China. sb.prove@163.com.
  • 3 School of Life Science and Biopharmaceutics, Shenyang Pharmaceutical University, Shenyang 110016, Liaoning, China. xmywd@vip.sina.com.
  • 4 School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, Liaoning, China. wangandong19891220@163.com.
  • 5 School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, Liaoning, China. cyl855@163.com.
  • 6 School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, Liaoning, China. liudongchun@outlook.com.
  • 7 Laboratory of China-Korea Molecular Pharmacognosy, Shenyang Pharmaceutical University, Shenyang 110016, Liaoning, China. liudongchun@outlook.com.
  • 8 School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, Liaoning, China. dongwang@syphu.edu.cn.
  • 9 Laboratory of China-Korea Molecular Pharmacognosy, Shenyang Pharmaceutical University, Shenyang 110016, Liaoning, China. dongwang@syphu.edu.cn.
PMID: 26999086 DOI: 10.3390/molecules21030349
Abstract

A new indole alkaloid named bufobutarginine (1), along with three known bufotenines, namely, serotonin (2), bufotenidine (3), and bufotenine (4), were isolated from the water extract of toad venom. Their structures were elucidated by spectral methods. This is the first time that arginine has been found to be involved in the biosynthesis of bufotenines in parotid of toad. The cytotoxic activities of these compounds have been assayed against A375 and A549 cell lines by the MTT method; however, they showed no cytotoxic activities.

Keywords

Bufo bufo gargarizans; bufobutarginine; cytotoxic activity; toad venom.

Figures
Products