2. Academic Validation
  3. Nitric Oxide Inhibitory Meroterpenoids from the Fungus Penicillium purpurogenum MHZ 111

Nitric Oxide Inhibitory Meroterpenoids from the Fungus Penicillium purpurogenum MHZ 111

  • J Nat Prod. 2016 May 27;79(5):1415-22. doi: 10.1021/acs.jnatprod.6b00160.
Jing Sun 1 2,  Zhi-Xiang Zhu 1,  Yue-Lin Song 1,  Dan Dong 3,  Jiao Zheng 1,  Ting Liu 3,  Yun-Fang Zhao 1,  Daneel Ferreira 4,  Jordan K Zjawiony 4,  Peng-Fei Tu 1,  Jun Li 1
Affiliations

Affiliations

  • 1 Modern Research Center for Traditional Chinese Medicine, Beijing University of Chinese Medicine , Beijing 100029, People's Republic of China.
  • 2 School of Chinese Materia Medica, Beijing University of Chinese Medicine , Beijing 100102, People's Republic of China.
  • 3 Institute of Plant and Environment Protection, Beijing Academy of Agriculture and Forestry Sciences , Beijing 100097, People's Republic of China.
  • 4 Department of BioMolecular Sciences, Division of Pharmacognosy, and Research Institute of Pharmaceutical Sciences, School of Pharmacy, University of Mississippi , University, Mississippi 38677-1848, United States.
PMID: 27120704 DOI: 10.1021/acs.jnatprod.6b00160
Abstract

Five new meroterpenoids, purpurogenolides A-E (1-5), and four known metabolites (6-9) were isolated from the solid substrate fermentation cultures of the fungus Penicillium purpurogenum MHz 111. The structures of the new meroterpenoids were elucidated by analysis of spectroscopic and spectrometric data (1D and 2D NMR, IR, and HRESIMS). The absolute configurations of 1 and 5 were determined by single-crystal X-ray crystallographic analysis, and those of 2-4 were elucidated on the basis of experimental and calculated electronic circular dichroism spectra. Compounds 2-4 and 6 showed inhibition of nitric oxide production in lipopolysaccharide-activated BV-2 microglial cells with IC50 values of 0.8-30.0 μM.

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