2. Academic Validation
  3. Bioactive Isoprenoid-Derived Natural Products from a Dongsha Atoll Soft Coral Sinularia erecta

Bioactive Isoprenoid-Derived Natural Products from a Dongsha Atoll Soft Coral Sinularia erecta

  • J Nat Prod. 2016 May 27;79(5):1339-46. doi: 10.1021/acs.jnatprod.5b01142.
Chiung-Yao Huang 1,  Yen-Ju Tseng 1,  Uvarani Chokkalingam 1,  Tsong-Long Hwang 2,  Chi-Hsin Hsu 1,  Chang-Feng Dai 3,  Ping-Jyun Sung 1 4,  Jyh-Horng Sheu 1 5 6 7
Affiliations

Affiliations

  • 1 Department of Marine Biotechnology and Resources, National Sun Yat-sen University , Kaohsiung 804, Taiwan.
  • 2 Graduate Institute of Natural Products, College of Medicine, Chang Gung University, Research Center for Industry of Human Ecology and Graduate Institute of Health Industry Technology, Chang Gung University of Science and Technology, Department of Anesthesiology, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan.
  • 3 Institute of Oceanography, National Taiwan University , Taipei 106, Taiwan.
  • 4 National Museum of Marine Biology & Aquarium , Pingtung 944, Taiwan.
  • 5 Institute of Natural Products, Kaohsiung Medical University , Kaohsiung 807, Taiwan.
  • 6 Department of Medical Research, China Medical University Hospital, China Medical University , Taichung 404, Taiwan.
  • 7 Frontier Center for Ocean Science and Technology, National Sun Yat-sen University , Kaohsiung 804, Taiwan.
PMID: 27142697 DOI: 10.1021/acs.jnatprod.5b01142
Abstract

Four new isoprenoids, including two norcembranoids sinulerectols A and B (1 and 2), a cembranoid sinulerectol C (3), and a degraded cembranoid sinulerectadione (4), along with three known isoprenoids, an unnamed norcembrene (5), sinularectin (6), and ineleganolide (7), and a known nitrogen-containing compound (Z)-N-[2-(4-hydroxyphenyl)ethyl]-3-methyldodec-2-enamide (8), were isolated from an extract of the marine soft coral Sinularia erecta. The structure of sinularectin (6) was revised, too. Compounds 3, 4, and 8 exhibited inhibitory activity against the proliferation of a limited panel of Cancer cell lines, whereas 1, 2, and 8 displayed potent anti-inflammatory activity in fMLP/CB-stimulated human neutrophils.

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