2. Academic Validation
  3. Synthesis of the olanzapine labeled by carbon-14

Synthesis of the olanzapine labeled by carbon-14

  • J Labelled Comp Radiopharm. 2016 Jun 30;59(8):325-7. doi: 10.1002/jlcr.3407.
Naghi Saadatjoo 1,  Mohsen Javaheri 1 2,  Nader Saemian 2,  Mohsen Amini 3
Affiliations

Affiliations

  • 1 Department of Organic Chemistry, Faculty of Chemistry, Semnan University, PO Box: 35131-19111, Semnan, Iran.
  • 2 Applied Radiations Research School, Nuclear Science & Technology Research Institute, Karegare Shomali Street, P.O. Box 11365-3486, Tehran, Iran.
  • 3 Department of Medicinal Chemistry, Faculty of Pharmacy and Drug Design & Development Research Center, Tehran University of Medical Sciences, Tehran, 14176, Iran.
PMID: 27146318 DOI: 10.1002/jlcr.3407
Abstract

Olanzapine is one of the most widely used antipsychotic drugs, which acts as an antagonist for multiple neurotransmitter receptor sites. 2-Methyl-4-(4-methyl-1-piperazinyl)-10H-thieno [2,3-b][1,5] benzodiazepine (Olanzapine) labeled with carbon-14 in the four positions has been synthesized as part of a three-step sequence from 2-amino-5-methylthiophene-3-carbonitrile-[carbonitrile-(14) C].

Keywords

antipsychotic; carbon-14; olanzapine.

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