2. Academic Validation
  3. The self-assembly of a camptothecin-lysine nanotube

The self-assembly of a camptothecin-lysine nanotube

  • Bioorg Med Chem Lett. 2016 Jun 15;26(12):2834-2838. doi: 10.1016/j.bmcl.2016.04.056.
Yuan Sun 1,  Aileen Shieh 1,  Se Hye Kim 1,  Samantha King 1,  Anne Kim 1,  Hui-Lung Sun 2,  Carlo M Croce 2,  Jon R Parquette 1
Affiliations

Affiliations

  • 1 Department of Chemistry and Biochemistry, The Ohio State University, 100 W. 18th Ave., Columbus, OH 43210, USA.
  • 2 Department of Molecular Virology Immunology and Medical Genetics, The Ohio State University, 460 W. 12th Ave., Columbus, OH 43210, USA.
PMID: 27156772 DOI: 10.1016/j.bmcl.2016.04.056
Abstract

A simple, low molecular weight camptothecin-lysine conjugate is reported to self-assemble into nanotubes with diameters of 70-100nm and a drug loading level of 60.5%. The nanotubes exhibited promising in vitro cytotoxicity against Cancer cell lines A549, NCI-H460 and NCI-H23. The release of active camptothecin was highly dependent on conjugate concentration, temperature and pH of the solution.

Keywords

Cytotoxicity; Drug delivery; Nanoparticle; Nanotube; Self-assembly.

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