2. Academic Validation
  3. Pyristriatins A and B: Pyridino-Cyathane Antibiotics from the Basidiomycete Cyathus cf. striatus

Pyristriatins A and B: Pyridino-Cyathane Antibiotics from the Basidiomycete Cyathus cf. striatus

  • J Nat Prod. 2016 Jun 24;79(6):1684-8. doi: 10.1021/acs.jnatprod.6b00194.
Christian Richter 1,  Soleiman E Helaly 1 2,  Benjarong Thongbai 3,  Kevin D Hyde 3,  Marc Stadler 1
Affiliations

Affiliations

  • 1 Department of Microbial Drugs, Helmholtz Centre for Infection Research; and German Centre for Infection Research (DZIF) , partner site Hannover/Braunschweig, Inhoffenstrasse 7, 38124 Braunschweig, Germany.
  • 2 Department of Chemistry, Faculty of Science, Aswan University , Aswan 81528, Egypt.
  • 3 Institute of Excellence in Fungal Research and School of Science, Mae Fah Luang University , Chiang Rai 57100, Thailand.
PMID: 27231731 DOI: 10.1021/acs.jnatprod.6b00194
Abstract

Two novel pyridino-cyathane Diterpenoids, pyristriatins A and B (1 and 2), together with striatin C (3) were isolated from cultures of Cyathus cf. striatus, a basidiomycete that was found during a field trip in northern Thailand. The pyristriatins showed antimicrobial effects against Gram-positive bacteria and fungi. The isolation, structure elucidation, relative configuration, and biological and cytotoxic activity are described. Their structures were assigned by HRMS and NMR spectroscopy. We also describe the first 2D NMR assignment of striatin C. Pyristriatins A and B are the first cyathane Natural Products featuring a pyridine ring.

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